Appraise and debate the sampling methods and determine the quality of the sampling procedures in reducing bias. Consider the following questions:Was the sampling method and inclusion/exclusion criteria adequate to reduce sampling bias?Are the sample characteristics representative of the target population?Was the sample size adequate?Was there a decrease in sample size?  If so, did the researchers identify decreases early and attempt to reduce the impact?  Was a decrease, if any, adequately explained by the researchers?

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